Wenbin Mei’s Cell paper on PCSK9 and inherited breast cancer metastasis risk
publication
genetics
New work in Cell identifies a commonly inherited PCSK9 germline variant that drives breast cancer metastasis via the LRP1 receptor.
Congratulations to Wenbin Mei and the team on their Cell paper: A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor.
A commonly inherited PCSK9 germline variant promotes breast cancer metastasis through LRP1 signaling, identifying a heritable driver of metastatic risk and a candidate therapeutic axis.